HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 6-(N,N-Dimethylamino)-4-[4-(1-phenyl-1-cyanomethyl)anilino]pyrido[3,4-d]pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2-(4-Aminophenyl)-2-phenylacetonitrile | HCID 116771 | — |
| Reactant | 4-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine | HCID 22727453 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(N,N-Dimethylamino)-4-[4-(1-phenyl-1-cyanomethyl)anilino]pyrido[3,4-d]pyrimidine hydrochloride | HCID 22112890 | — |
Reaction Steps
Prepared according to Procedure A from 4-chloro-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine and (4-aminophenyl)-phenylacetonitrile (commercially available from Salor); tlc (dichloromethane:ethanol:aq.ammonia, 100:8:1) Rf 0.43; m/z (M+1)+381.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169091A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-ec525adb89f34c299045ec78d7c720e1 |
| Source note | uspto-grants-2001_01 |