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HRID5648

反应详情

EQUATION

反应方程式

HRID 5648 的结构方程式

REACTANTS

反应物

4
结构：[Cl-]
HCID312

Chloride

Cl-

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CCOC(=O)C1=C(CSC(=N)N)NC(C)=C(C#N)C1c1cccc([N+](=O)[O-])c1
HCID19796447

未命名化合物

结构：Cl.ClCc1ccc[nH+]c1
HCID21477773

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(CSCc2cccnc2)NC(C)=C(C#N)C1c1cccc([N+](=O)[O-])c1
HCID67863868

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A mixture of (-)-S-[(5-cyano-3-carboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridin-2-yl)methyl]isothiourea (mg 500), 3-chloromethylpyridinium hydrochloride (mg 190), benzylthriethylammonium chloride (BTEAC mg 80), KOH (4M, ml 2) and benzene (ml 5) is stirred at room temperature for 15 minutes to separate a precipitate that is filtered and triturated with diethyl ether to give mg 450 of (-)-2-(3-pyridinylmethylthio)methyl-5-cyano-3-carboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine.

WORKUP

后处理

  1. customto separate a precipitate that
  2. filtrationis filtered
  3. customtriturated with diethyl ether