反应详情

5-[1-(4-benzyloxyindol-3-yl)ethyl]-2-methylamino-2-oxazolin-4-one (149 mg) was dissolved in a mixture of ethanol and tetrahydrofuran (5:1.6 ml). 10% palladium-carbon (45 mg) was added and the whole was hydrogenated for 24 hours at room temperature under normal pressure. The catalyst was removed from the mixture by filtration and 10% palladium-carbon (45 mg) was added again. The whole was hydrogenated for additional 24 hours at room temperature under normal pressure. The reaction mixture was filtered to remove the catalyst. The filtrate was concentrated to give a residue, which was subjected to silica gel chromatography. Elution with hexane-acetone (1:1) provided the titled compound (72 mg).

1. customThe catalyst was removed from the mixture by filtration and 10% palladium-carbon (45 mg)
2. additionwas added again
3. waitThe whole was hydrogenated for additional 24 hours at room temperature under normal pressure
4. filtrationThe reaction mixture was filtered
5. customto remove the catalyst
6. concentrationThe filtrate was concentrated
7. customto give a residue, which
8. washElution with hexane-acetone (1:1)