反应详情

A mixture of 8-[2,6-dichloro-3-[N-(phthalimido-acetyl)-N-methylamino]benzyloxy)-2-methylquinoline (3.98 g), hydrazine monohydrate (0.72 ml) and ethanol (40 ml) was heated under reflux for 1 hour. The precipitate was removed by vacuum filtration and the filtrate was evaporated in vacuo. The residue was dissolved with dichloromethane and the precipitate was removed by vacuum filtration. The filtrate was evaporated in vacuo to give 8-[3-(N-glycyl-N-methylamino)-2,6-dichlorobenzyloxy)-2-methylquinoline (2.99 g) as a yellow amorphous powder.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. customThe precipitate was removed by vacuum filtration
4. customthe filtrate was evaporated in vacuo
5. dissolutionThe residue was dissolved with dichloromethane
6. customthe precipitate was removed by vacuum filtration
7. customThe filtrate was evaporated in vacuo