Guanidine Hydrochloride → HCID 178485137, compound

HRID 565012Notes

Reaction equation

HRID 565012 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:12]([O:14]C)=O)[N:6]2C.Cl.[NH2:17][C:18]([NH2:20])=[NH:19].[CH3:21][O-].[Na+]>CO>[ClH:1].[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:12]([N:19]=[C:18]([NH2:20])[NH:17][CH3:21])=[O:14])[NH:6]2

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 4777691HCID 4777691, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 178485137HCID 178485137, compoundYield 82.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 1 except for using 2.00 g (8.94 mmol) of methyl 4-chloro-1-methyl-2-indolecarboxylate, 8.54 g (89.4 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 4.83 g (89.4 mmol) of sodium methoxide. Thus 1.06 g (41.3%) of 4-chloro-1-methyl-2-indoloylguanidine hydrochloride was obtained.

Sources & evidence

ORD record
ord-19c1737462a5406caa527cfe0baa2848
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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