Guanidine Hydrochloride → HCID 178485158, compound

HRID 565020Notes

Reaction equation

HRID 565020 reaction equation
[C:1]([NH:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[CH:7]=[C:8]([C:15]([O:17]CC)=O)[N:9]2C)(=[O:3])[CH3:2].[ClH:20].[NH2:21][C:22]([NH2:24])=[NH:23].[CH3:25][O-].[Na+]>CO>[ClH:20].[C:1]([NH:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[CH:7]=[C:8]([C:15]([N:23]=[C:22]([NH2:24])[NH:21][CH3:25])=[O:17])[NH:9]2)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194389Ethyl 4-acetamido-1-methyl-2-indolecarboxylate

Product 1

HCID 178485158HCID 178485158, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 1 except for using 1.40 g (5.38 mmol) of ethyl 4-acetamido-1-methyl-2-indole-carboxylate, 5.14 g (53.8 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.91 g (53.8 mmol) of sodium methoxide. Thus 1.15 g (69.0%) of 4-acetamido-1-methyl-2-indoloylguanidine hydrochloride was obtained.

Sources & evidence

ORD record
ord-61e90bd8e13b486cb31493706a0cb61b
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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