Guanidine Hydrochloride → HCID 178479357, compound

HRID 565022Notes

Reaction equation

HRID 565022 reaction equation
O[N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11]([O:13]C)=O.[ClH:15].[NH2:16][C:17]([NH2:19])=[NH:18].C[O-:21].[Na+]>CO>[ClH:15].[OH:21][NH:18][C:17]([NH2:19])=[N:16][C:11]([C:3]1[NH:2][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2)=[O:13]

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194070HCID 21194070, compound

Product 1

HCID 178479357HCID 178479357, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 1 except for using 1.00 g (5.23 mmol) of methyl 1-hydroxy-2-indolecarboxylate, 5.00 g (52.3 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.82 g (52.3 mmol) of sodium methoxide. 1-Hydroxy-2-indoloylguanidine hydrochloride was obtained in an amount of 0.56 g (42.0%).

Sources & evidence

ORD record
ord-5d945b79aca149fe946f2468721b1def
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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