Guanidine Hydrochloride → HCID 178485152, compound

HRID 565026Notes

Reaction equation

HRID 565026 reaction equation
[C:1]([NH:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[N:15](C)[C:14]([C:20]([O:22]CC)=O)=[CH:13]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:25].[NH2:26][C:27]([NH2:29])=[NH:28].[CH3:30][O-].[Na+]>CO>[ClH:25].[C:1]([NH:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]([C:20]([N:28]=[C:27]([NH2:29])[NH:26][CH3:30])=[O:22])=[CH:13]2)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194638Ethyl 5-benzamido-1-methyl-2-indolecarboxylate

Product 1

HCID 178485152HCID 178485152, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 1 except for using 0.62 g-(1.92 mmol) of ethyl 5-benzamido-1-methyl-2-indole-carboxylate, 3.68 g (38.4 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.08 g (38.4 mmol) of sodium methoxide. 5-Benzamido-1-methyl-2-indoloylguanidine hydrochloride was obtained in an amount of 0.38 g (53.1%).

Sources & evidence

ORD record
ord-9aeeb84b1ae048a8b291e76e3a271110
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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