Stannous chloride dihydrate → HCID 178485140, compound

HRID 565046Notes

Reaction equation

HRID 565046 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[CH:13]=2)=[C:7]2[C:3]=1[CH:4]=[C:5]([C:21]([N:23]=[C:24]([NH2:27])[NH:25][CH3:26])=[O:22])[NH:6]2.O.O.[Sn](Cl)Cl>C(O)C>[ClH:1].[NH2:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][C:8]1[CH:9]=[CH:10][C:2]([Cl:1])=[C:3]2[C:7]=1[NH:6][C:5]([C:21]([N:23]=[C:24]([NH2:27])[NH:25][CH3:26])=[O:22])=[CH:4]2

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 178485141HCID 178485141, compound

Product 1

HCID 178485140HCID 178485140, compoundYield 130.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 186 c) except for using 0.055 g (0.14 mmol) of 4-chloro-1-methyl-7-(3-nitrophenoxy)-2-indoloylguanidine, 0.16 g (0.71 mmol) of tin (II) chloride dihydrate and 5 ml of ethanol. Thus, 0.036 g (59.0%) of 7-(3-aminophenoxy)-4-chloro-1-methyl-2-indoloylguanidine hydrochloride was obtained.

Sources & evidence

ORD record
ord-0703578a1398464fbc4fbe96ec58b52a
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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