Guanidine Hydrochloride → HCID 178485151, compound

HRID 565048Notes

Reaction equation

HRID 565048 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:22]([O:24]CC)=O)[N:6]2C.Cl.[NH2:28][C:29]([NH2:31])=[NH:30].[CH3:32][O-].[Na+]>CO>[Cl:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:22]([N:30]=[C:29]([NH2:31])[NH:28][CH3:32])=[O:24])[NH:6]2

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194089Ethyl 4-chloro-1-methyl-6-(4-nitrophenoxy)-2-indolecarboxylate

Product 1

HCID 178485151HCID 178485151, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 186 b) except for using 0.45 g (1.32 mmol) of ethyl 4-chloro-1-methyl-6-(4-nitrophenoxy)-2-indolecarboxylate, 2.52 g (26.4 mmol) of guanidine hydrochloride, 1.42 g (26.4 mmol) of sodium methoxide and 25 ml of methanol. Thus, 0.24 g (47.0%) of 4-chloro-1-methyl-6-(4-nitrophenoxy)-2-indoloylguanidine was obtained.

Sources & evidence

ORD record
ord-47363e92804f455ba7e3ceb66b906723
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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