Guanidine Hydrochloride → HCID 178485149, compound

HRID 565053Notes

Reaction equation

HRID 565053 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)[CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:23](OCC)=[O:24])[N:6]2C.[ClH:28].[NH2:29][C:30]([NH2:32])=[NH:31].[CH3:33][O-].[Na+]>CO>[ClH:1].[ClH:28].[Cl:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][N:19]([CH3:21])[CH3:20])=[CH:16][CH:17]=2)[CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:23]([N:31]=[C:30]([NH2:32])[NH:29][CH3:33])=[O:24])[NH:6]2

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 21194266HCID 21194266, compound

Product 1

HCID 178485149HCID 178485149, compoundYield 129.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction was carried out in a manner similar to Example 186 b) except for using 0.29 g (0.75 mmol) of ethyl 4-chloro-6-[4-(dimethylaminomethyl)phenoxy]-1-methyl-2-indolecarboxylate, 1.43 g (15.0 mmol) of guanidine hydrochloride, 0.81 g (15.0 mmol) of sodium methoxide and 30 ml of methanol. Thus, 0.23 g (66.0%) of 4-chloro-6-[4-(dimethylaminomethyl)phenoxy]-1-methyl-2-indoloylguanidine dihydrochloride was obtained.

Sources & evidence

ORD record
ord-d3f2dc65dedf45479f99eaec395a79e5
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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