反应详情

4-Hydroxyphenethyl alcohol (3.2 g) was dissolved in 50 ml of pyridine, to which 4.0 g of tosyl chloride was added in small portions under ice cooling. The temperature of the reaction mixture was allowed to rise to room temperature, at which it was stirred for 2 hours. Then, insoluble matter was filtered off, and pyridine was distilled off under reduced pressure. The residue was isolated and purified by chromatography on a silica gel column (eluent: CHCl3), whereby 3.4 g of the compound (1) were obtained (yield: 59%).

1. additionwas added in small portions under ice cooling
2. customto rise to room temperature, at which it
3. filtrationThen, insoluble matter was filtered off
4. distillationpyridine was distilled off under reduced pressure
5. customThe residue was isolated
6. custompurified by chromatography on a silica gel column (eluent: CHCl3)