Pyridine → HCID 129676065, compound

HRID 565169Notes

Reaction equation

HRID 565169 reaction equation
[C-:1]1([CH2:6][CH2:7][OH:8])[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH-:9]1[CH:13]=[CH:12][CH:11]=[CH:10]1.[Fe+2:14].N1C=CC=CC=1.[C:21](Cl)(=[O:25])[C:22]([CH3:24])=[CH2:23]>CCOCC>[C:21]([O:8][CH2:7][CH2:6][C-:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1)(=[O:25])[C:22]([CH3:24])=[CH2:23].[CH-:9]1[CH:13]=[CH:12][CH:11]=[CH:10]1.[Fe+2:14]

Participants

5

Reactant 3

HCID 1049PyridineHCID 13528Methacryloyl chlorideHCID 158548031273-90-1

Product 1

HCID 129676065HCID 129676065, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

2-ferrocenylethyl alcohol obtained from Example 1 (0.8 g) is dissolved in 300 ml anhydrous ether and 0.4 g of pyridine are added. The solution of 0.5 ml methacryloyl chloride in 30 ml ether is added dropwise and the reaction is continued for four hours. The precipitate is removed by filtration and the ether solutions are combined, washed with 5% sodium bicarbonate, 5% hydrochloric acid, sodium bicarbonate again and dried. The ether is evaporated, leaving a brown viscous oil that is further purified by chromatography over silica (ether as eluent).

Workup

  1. customThe precipitate is removed by filtration
  2. washwashed with 5% sodium bicarbonate, 5% hydrochloric acid, sodium bicarbonate again
  3. customdried
  4. customThe ether is evaporated
  5. customleaving a brown viscous oil that
  6. customis further purified by chromatography over silica (ether as eluent)

Sources & evidence

ORD record
ord-b96af9e04a024af187bd776c78dc9246
Source dataset
uspto-grants-2001_01
Patent number
US06171757B2

Reaction notes

Loading…