HCID 21267689, compound → HCID 21267691, compound

HRID 565187Notes

Reaction equation

HRID 565187 reaction equation
[N+:1]([C:4]1[C:12]([O:13][CH2:14][CH3:15])=[CH:11][C:7]([CH2:8][CH2:9][NH2:10])=[C:6]([O:16][CH2:17][CH3:18])[CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[C:12]([O:13][CH2:14][CH3:15])=[CH:11][C:7]([CH2:8][CH2:9][NH2:10])=[C:6]([O:16][CH2:17][CH3:18])[CH:5]=1

Participants

5

Reactant 2

HCID 21267689HCID 21267689, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21267691HCID 21267691, compoundYield 102%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3.05 g (12.0 mmol) 4-nitro-2,5-diethoxyphenethylamine N6 was dissolved in 50 ml ethanol, and 1.5 g 10% palladium on carbon black was added. This suspension was hydrogenated at 2.2 atm. for 18 hours, till no more hydrogen uptake was observed. The catalyst was filtered off and the solvent was evaporated to afford 2.75 g light yellow oil (yield: 102%).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-47eca309facf4511b991ad4c8833121e
Source dataset
uspto-grants-2001_01
Patent number
US06171866B2

Reaction notes

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