Piperidine → HCID 22725230, compound

HRID 565214Notes

Reaction equation

HRID 565214 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1[F:10])[CH:5]=O.[CH3:12][C:13](=[O:18])[CH2:14][C:15](=[O:17])[CH3:16].N1CCCCC1>C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:14]([C:13](=[O:18])[CH3:12])[C:15](=[O:17])[CH3:16])[CH:7]=[C:8]([F:11])[C:9]=1[F:10]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 31261AcetylacetoneHCID 27769543,4,5-Trifluorobenzaldehyde

Product 1

HCID 22725230HCID 22725230, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 3,4,5-trifluorobenzaldehyde (4.2 g, 26.2 mmol), 2,4-pentanedione (2.62 g, 26.2 mmol), piperidine (0.430 g, 5 mmol) in benzene (150 mL) was stirred and refluxed with a Dean-Stark trap for 8 hours. Benzene was evaporated and the yellow oily residue, 2-{(3,4,5-trifluorophenyl)methylene}-2,4-pentanedione, was used in the next step without any further purification.

Workup

  1. temperaturerefluxed with a Dean-Stark trap for 8 hours
  2. customBenzene was evaporated
  3. customthe yellow oily residue, 2-{(3,4,5-trifluorophenyl)methylene}-2,4-pentanedione, was used in the next step without any further purification

Sources & evidence

ORD record
ord-6867d7904c424f3187ee2f8027162918
Source dataset
uspto-grants-2001_01
Patent number
US06172066B2

Reaction notes

Loading…