Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Dimethylimidazolium Iodide → 6,7-Dimethoxyquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Dimethylimidazolium Iodide | HCID 20334 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-Bromobenzaldehyde | HCID 76583 | — |
| 반응물 | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 6,7-Dimethoxyquinazoline | HCID 3031661 | — |
반응 단계
The lead compound 4-(3′-bromobenzoyl)-6,7-dimethoxyquinazoline WHI-P164 was synthesized by reacting 4-chloro-6,7-dimethoxyquinazoline 5 with the commercially available 3-bromobenzaldehyde in the presence of 1,3-dimethylimidazolium iodide and sodium hydride in refluxing dioxane for 4 hours (Scheme 2) (32,33). The remaining 6,7-dimethoxyquinazoline derivatives were synthesized by condensing 4-chloro-6,7-dimethoxyquinazoline 5 with the corresponding substituted anilines as shown in Scheme 3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06172071B2 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-d01608871e9a4e309a5955edd3dfac79 |
| 출처 메모 | uspto-grants-2001_01 |