2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester → 2-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid

HRID 565287Notes

Reaction equation

HRID 565287 reaction equation
C([O:3][C:4](=[O:37])[C:5]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH2:29][N:30]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)=[CH:23][CH:22]=1)([S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)(=[O:11])=[O:10])[CH2:6][CH2:7][CH3:8])C>CO.[OH-].[Na+]>[N:30]1([CH2:29][CH2:28][O:27][C:24]2[CH:23]=[CH:22][C:21]([CH2:20][C:5]([S:9]([C:12]3[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=3)(=[O:10])=[O:11])([CH2:6][CH2:7][CH3:8])[C:4]([OH:37])=[O:3])=[CH:26][CH:25]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

4

Reactant 1

HCID 544916962-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester

Product 1

HCID 184168052-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

2-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid was prepared starting from 2-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid ethyl ester (2 g, 3.76 mmol) dissolved in methanol (300 ml) and 10 N NaOH (15 ml). The resulting mixture was worked up as outlined in example 1. Yield 830 mg (44%); brown solid; mp 55° C.; MS: 504.4 (M+H)+.

Sources & evidence

ORD record
ord-95ac716b085f4e8994542e7aaadf8bbe
Source dataset
uspto-grants-2001_01
Patent number
US06172057B2

Reaction notes

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