HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester → 2-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester | HCID 54491696 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid | HCID 18416805 | — |
Reaction Steps
2-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid was prepared starting from 2-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid ethyl ester (2 g, 3.76 mmol) dissolved in methanol (300 ml) and 10 N NaOH (15 ml). The resulting mixture was worked up as outlined in example 1. Yield 830 mg (44%); brown solid; mp 55° C.; MS: 504.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172057B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-95ac716b085f4e8994542e7aaadf8bbe |
| Source note | uspto-grants-2001_01 |