反应详情

温度

80 °C

To a solution of 3,5-dimethoxy-4-methylphenyl trifluoromethanesulfonate (0.50 g, 1.67 mmol) in DME (15 mL) was added 2-furylboronic acid (0.245 g, 2.2 mmol), LiCl (0.149 g, 3.5 mmol), 2 M aqueous Na2CO3 (1.8 mL, 3.6 mmol) and tetrakis(triphenylphosphine)palladium (0.098 g, 0.085 mmol) and the mixture was degassed as described previously. The reaction was heated at 80° C. under argon for 22 hrs. After cooling to room temperature, the reaction was diluted with H2O and extracted with EtOAc. The combined organics were washed with H2O, saturated aqueous NH4Cl, H2O and brine, dried over Na2SO4 and concentrated in vacuo. Purification by chromatography (0-25% Et2O-hexanes) gave 2-(3,5-dimethoxy-4-methylphenyl)furan as a white solid (0.28 g, 77% yield).

1. customthe mixture was degassed
2. temperatureAfter cooling to room temperature
3. additionthe reaction was diluted with H2O
4. extractionextracted with EtOAc
5. washThe combined organics were washed with H2O, saturated aqueous NH4Cl, H2O and brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated in vacuo
8. customPurification by chromatography (0-25% Et2O-hexanes)