Methylamine → HCID 9930976, compound

Participants

Reaction Steps

A solution of 2-chloro-1-[1-(1-phenylcycloheptyl)-4-piperidinyl]benzimidazole (Example 1, 69.3 mg, 0.17 mmol) in 40% MeNH2 solution in MeOH (5 ml) was stirred in autoclave at 110° C. for 6 h. After cooling down to room temperature, the solvent was evaporated and the residue was purified by preparative TLC (0.5 mm plate×3, CH2Cl2/MeOH:10/1) to give 56.9 mg(83%) of title compound as pale brown amorphous solid.

Provenance & Evidence