Methylamine → HCID 9930976, compound

HRID 565369Notes

Reaction equation

HRID 565369 reaction equation
Cl[C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][N:10]([C:13]3([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[CH2:9][CH2:8]2)[C:5]2[CH:26]=[CH:27][CH:28]=[CH:29][C:4]=2[N:3]=1.[CH3:30][NH2:31]>CO>[CH3:30][NH:31][C:2]1[N:6]([CH:7]2[CH2:8][CH2:9][N:10]([C:13]3([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]3)[CH2:11][CH2:12]2)[C:5]2[CH:26]=[CH:27][CH:28]=[CH:29][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 11373168HCID 11373168, compound

Product 1

HCID 9930976HCID 9930976, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-chloro-1-[1-(1-phenylcycloheptyl)-4-piperidinyl]benzimidazole (Example 1, 69.3 mg, 0.17 mmol) in 40% MeNH2 solution in MeOH (5 ml) was stirred in autoclave at 110° C. for 6 h. After cooling down to room temperature, the solvent was evaporated and the residue was purified by preparative TLC (0.5 mm plate×3, CH2Cl2/MeOH:10/1) to give 56.9 mg(83%) of title compound as pale brown amorphous solid.

Workup

  1. customthe solvent was evaporated
  2. customthe residue was purified by preparative TLC (0.5 mm plate×3, CH2Cl2/MeOH:10/1)

Sources & evidence

ORD record
ord-0441ff9571204bc7b9f37ea9b8856214
Source dataset
uspto-grants-2001_01
Patent number
US06172067B2

Reaction notes

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