Fumaric Acid → HCID 21268360, compound

HRID 565387Notes

Reaction equation

HRID 565387 reaction equation
[CH2:1]1[CH:10]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]2)[CH2:3][CH:2]1[N:11]1[CH2:27][CH2:26][C:14]2([N:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:17][CH2:16][CH:15]2[OH:25])[CH2:13][CH2:12]1.[C:28]([O-:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([O-:33])=[O:32].C(O)(=O)/C=C/C(O)=O>C(OCC)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[CH2:1]1[CH:10]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]2)[CH2:3][CH:2]1[N:11]1[CH2:27][CH2:26][C:14]2([N:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:17][CH2:16][C:15]2=[O:25])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 444972Fumaric AcidHCID 5460307FumarateHCID 15411835HCID 15411835, compound

Product 1

HCID 21268360HCID 21268360, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Oxidation of 8-(decahydro-azulen-2-yl)-1-phenyl-1,8-diaza-spiro[4.5]decan-4-ol (mixture of diastereoisomers) according to the general method of example 20 and formation of the fumarate with fumaric acid in diethyl ether yielded the title compound, pale brown solid, m.p. 219° C. and MS: m/e=367.3 (M+H+).

Sources & evidence

ORD record
ord-c118da31ddc747bc9674c100eb310e89
Source dataset
uspto-grants-2001_01
Patent number
US06172075B2

Reaction notes

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