反应详情

7-Amino-8-methylguinoline. To a solution of 1.45 g of 8-methyl-7-nitroquinoline in 20 mL of ethanol are added 1.45 g of ammonium formate and a catalytic amount of 10% palladium-on-carbon. The resulting suspension is stirred at room temperature for 3 hours. The reaction mixture is filtered on Celite, with a methanol wash of the solids, and the filtrate is rotary evaporated. The residue is purified by flash column chromatography on silica gel, eluting with 50% ethyl acetate/hexanes followed by recrystallization from hexanes/methylene chloride to provide 1.10 g of 7-amino-8-methylquinoline as a pale yellow solid.

1. filtrationThe reaction mixture is filtered on Celite, with a methanol
2. washwash of the solids
3. customThe residue is purified by flash column chromatography on silica gel
4. washeluting with 50% ethyl acetate/hexanes
5. customfollowed by recrystallization from hexanes/methylene chloride