反应详情

0.0755 mol (21.78 g) of the product from stage 1 is stirred at 60° C. for 5 days in 1.51 liters of a 0.01 molar lithium hydroxide solution in a tetrahydrofuran/water 1:1 mixture. The mixture is acidified with aqueous citric acid and the product is extracted with ethyl acetate. The organic phase is washed with water, dried over sodium sulfate and concentrated under reduced pressure.

1. extractionthe product is extracted with ethyl acetate
2. washThe organic phase is washed with water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure