反应详情

In a reactor fitted with a water trap, a mixture of benzhydrol (5.0 g), 3-bromo-1-propanol (3.8 g), camphor-10-sulfonic acid (1.0 g), and toluene (80 mL) was refluxed for 2 hours. This reaction mixture was concentrated and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=95:5) to provide 7.0 g of the title compound. Yield 85%.

1. customIn a reactor fitted with a water trap
2. temperaturewas refluxed for 2 hours
3. concentrationThis reaction mixture was concentrated
4. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=95:5)