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In a reactor fitted with a water trap, a mixture of benzhydrol (3.7 g), 4-piperidinemethanol (2.3 g), camphor-10-sulfonic acid (7.0 g), and toluene (30 mL) was refluxed for 2 hours. After cooling, 35 mL of 1N-aqueous sodium hydroxide was added and the reaction mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous NaCl, dried over MgSO4, and concentrated under reduced pressure to provide 5.3 g of the title compound. Yield 94%. This product was not further purified but directly submitted to the next reaction.

1. customIn a reactor fitted with a water trap
2. temperaturewas refluxed for 2 hours
3. temperatureAfter cooling
4. extractionthe reaction mixture was extracted with ethyl acetate
5. washThe extract was washed with saturated aqueous NaCl
6. dry with materialdried over MgSO4
7. concentrationconcentrated under reduced pressure