Piperazine → 1-Phenethylpiperazine

HRID 565642Notes

Reaction equation

[CH:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8]Br)=[CH:3][CH:2]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[C:4]1([CH2:7][CH2:8][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 7666Phenethyl bromide

Product 1

HCID 792141-PhenethylpiperazineYield 92%

Procedure

Using β-phenethyl bromide and piperzine, the procedure of Reference Example 16 was otherwise repeated to provide the title compound. Yield 92%.

Sources & evidence

ORD record: ord-0f5e8beaabba4fe6b0c14921dcbe65d2
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06172085B2

Reaction notes

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