P-Toluic Acid → HCID 22110966, compound

HRID 565648Notes

Reaction equation

HRID 565648 reaction equation
[CH3:1][C:2]1([CH2:15][N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH2:6][C:5]2[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=2[O:3]1.[CH3:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=1>>[CH3:1][C:2]1([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:27](=[O:28])[C:26]3[CH:30]=[CH:31][C:23]([CH3:22])=[CH:24][CH:25]=3)[CH2:18][CH2:17]2)[CH2:6][C:5]2[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 7470P-Toluic AcidHCID 219977792,3-Dihydro-2,4,6,7-tetramethyl-2-[(1-piperazinyl)methyl]-5-benzofuranamine

Product 1

HCID 22110966HCID 22110966, compoundYield 53%

Procedure

Using 2,3-dihydro-2,4,6,7-tetramethyl-2-[(1-piperazinyl)methyl]-5-benzofuranamine and 4-methylbenzoic acid, the procedure of Example 10, presented hereinafter, was otherwise followed to provide the title compound. Yield 53%.

Sources & evidence

ORD record
ord-736f2acd28924d42b78f5632d534db90
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Reaction notes

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