反应详情

温度

120 °C

To a heated (110° C.) mixture of 4-piperidone monohydrate hydrochloride (8.2 g), acetic acid (15 mL) and trifluoroacetic acid (30 mL) was added 1-phenyl-1H-indole (3.1 g) under nitrogen atmosphere over a period of 25 min. The mixture was stirred for 30 minutes at 120° C., then cooled and poured into ice. This was neutralized with conc. ammonia water under cooling and the product was extracted thrice with ethyl acetate. The combined extract was washed with water followed by saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was provided for the next reaction without further purification. Yield 63%. Amorphous.

1. temperatureTo a heated
2. temperaturecooled
3. additionpoured into ice
4. temperatureunder cooling
5. extractionthe product was extracted thrice with ethyl acetate
6. extractionThe combined extract
7. washwas washed with water
8. dry with materialdried over anhydrous magnesium sulfate
9. filtrationfiltered
10. customevaporated
11. customThe residue was provided for the next reaction without further purification