Hydrochloric Acid → HCID 9959917, compound

HRID 565698Notes

Reaction equation

HRID 565698 reaction equation
[NH2:1][C:2]1[C:3]([CH3:35])=[C:4]([CH3:34])[C:5]2[O:9][C:8]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:14][CH2:13]3)([CH3:10])[CH2:7][C:6]=2[C:32]=1[CH3:33].[ClH:36]>C(O)C>[ClH:36].[ClH:36].[ClH:36].[NH2:1][C:2]1[C:3]([CH3:35])=[C:4]([CH3:34])[C:5]2[O:9][C:8]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:14][CH2:13]3)([CH3:10])[CH2:7][C:6]=2[C:32]=1[CH3:33]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9959918HCID 9959918, compound

Product 1

HCID 9959917HCID 9959917, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-[(5-Amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-(diphenylmethyl)-4-piperidineamine (2.2 g) was treated with 4N-HCl solution in ethanol and the resulting trihydrochloride was recrystallized from ethanol/diethyl ether to provide 2.5 g of the title compound. Yield 87%.

Workup

  1. customthe resulting trihydrochloride was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-61413a1665ea466caa14fac39582bdc3
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Reaction notes

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