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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 565706Generated: October 29, 2026

2-Bromomethyl-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamine → 1-[(5-Amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-[bis(4-methoxyphenyl)methyl]-4-piperidinamine

https://huagongshe.com/reaction/565706

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromomethyl-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamineHCID 10850590—
ReactantN-[bis(4-methoxyphenyl)methyl]-4-piperidinamineHCID 22111110—
Product1-[(5-Amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-[bis(4-methoxyphenyl)methyl]-4-piperidinamineHCID 2211111143%

Reaction Steps

Starting with 2-bromomethyl-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamine and N-[bis(4-methoxyphenyl)methyl]-4-piperidinamine, the procedure of Example 53 was otherwise repeated to provide the title compound. Yield 43%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06172085B2
Source datasetuspto-grants-2001_01
ORD IDord-3b6f516591944037a20125d977bcd5c3
Source noteuspto-grants-2001_01