Benzylamine → HCID 178507982, compound

Participants

Reaction Steps

2.7 ml of benzylamine was added to a solution of 5.0 g of the 2,4-dichloro-5-nitropyrimidine (Reference Example 1) in 75 ml of dichloromethane at 5° C. and the solution was stirred for 1 hour. 3.6 ml of triethylamine was added to the solution at 5° C., stirred for 10 minutes, washed with 150 ml of saturated sodium bicarbonate, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 6.6 g of the title compound.

Provenance & Evidence