Benzylamine → HCID 178507982, compound

HRID 565713Notes

Reaction equation

HRID 565713 reaction equation
[CH2:1](N)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[N:15]=[C:14](Cl)[C:13]([N+:17]([O-:19])=[O:18])=[CH:12][N:11]=1.C([N:22](CC)CC)C>ClCCl>[CH2:1]([C:12]1[C:13]([N+:17]([O-:19])=[O:18])=[CH:14][NH:15][C:10]([Cl:9])([NH2:22])[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7504BenzylamineHCID 8471TriethylamineHCID 5212662,4-Dichloro-5-nitropyrimidine

Product 1

HCID 178507982HCID 178507982, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.7 ml of benzylamine was added to a solution of 5.0 g of the 2,4-dichloro-5-nitropyrimidine (Reference Example 1) in 75 ml of dichloromethane at 5° C. and the solution was stirred for 1 hour. 3.6 ml of triethylamine was added to the solution at 5° C., stirred for 10 minutes, washed with 150 ml of saturated sodium bicarbonate, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 6.6 g of the title compound.

Workup

  1. stirringstirred for 10 minutes
  2. washwashed with 150 ml of saturated sodium bicarbonate
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-887245d431dc47a7aa06929cb0a52805
Source dataset
uspto-grants-2001_01
Patent number
US06172227B2

Reaction notes

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