反应详情

温度

60 °C

To N-[(S)-α-methylbenzyl]-(S)-proline methyl ester (4.46 g) obtained in Example 3 were added water (9.33 g) and 2-ethylhexanoic acid (3.25 g). The mixture was heated up to 60° C. and stirred at that temperature for 12 hours. The resulting mixture was washed with heptane to yield an aqueous N-[(S)-α-methylbenzyl]-(S)-proline solution.

1. washThe resulting mixture was washed with heptane