3-Amino-1-propanol → HCID 22111553, compound

HRID 565733Notes

Reaction equation

HRID 565733 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][S:7](Cl)(=[O:9])=[O:8].[CH2:11]([CH2:14][OH:15])[CH2:12][NH2:13]>>[OH:15][CH2:14][CH2:11][CH2:12][NH:13][S:7]([CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][Cl:1])(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 12589202HCID 12589202, compound

Product 1

HCID 22111553HCID 22111553, compound

Procedure

The reaction was carried out in the same manner as in Preparation Example 4 except for using 5-chloropentanesulfonyl chloride (3.08 g, 15 mmol) in place of 6-chlorohexanesulfonyl chloride, and n-propanolamine (2.48 g, 33 mmol) in place of ethanolamine in Preparation Example 4, to give a by-product [N,O-bis(5-chloropetanesulfonyl)propanolamine] from a first eluted fraction in the amount of 0.64 g and N-(3-hydroxypropyl)-5-chloropentanesulfonamide from a second eluted fraction as a colorless waxy product in the amount of 2.76 g.

Workup

  1. customThe reaction was carried out in the same manner as in Preparation Example 4 except
  2. customin Preparation Example 4

Sources & evidence

ORD record
ord-18f20c6e0940413a80a07591ecb3f251
Source dataset
uspto-grants-2001_01
Patent number
US06172228B2

Reaction notes

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