Ammonia → N-(3-Chlorophenyl)benzenemethanamine

HRID 565739Notes

Reaction equation

HRID 565739 reaction equation
C(C(C(C(O)=O)O)O)(O)=O.[Cl:11][C:12]1[CH:13]=[C:14]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:15]=[CH:16][CH:17]=1.N>C(Cl)(Cl)Cl>[Cl:11][C:12]1[CH:13]=[C:14]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86756217HCID 86756217, compound

Product 1

HCID 11506782N-(3-Chlorophenyl)benzenemethanamineYield 96.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Next, (+)-(3-chlorophenyl)phenylmethylamine (+)tartrate (4.28 g) was suspended in chloroform (40 ml), and 28%-aqueous ammonia was added thereto to neutralize the mixture. Thereafter, the chloroform layer was separated therefrom. The extract was dried over anhydrous magnesium sulfate, and the solvent was removed by evaporation in vacuo, to give (+)-(3-chlorophenyl)phenylmethylamine (2.45 g) as a pale yellow oil.

Workup

  1. customThereafter, the chloroform layer was separated
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. customthe solvent was removed by evaporation in vacuo

Sources & evidence

ORD record
ord-c26e0cf2cd824304818775200eedf1f3
Source dataset
uspto-grants-2001_01
Patent number
US06172228B2

Reaction notes

Loading…