Hydrogen Bromide → HCID 69988954, compound

Participants

Reaction Steps

N-Cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide (0.50 g, 1.02 mmol) prepared in the same manner as in Example 1 was dissolved in methanol (20 ml). A 47% hydrobromic acid solution (0.47 g, 2.75 mmol) was added thereto, and the solvent was then removed by evaporation in vacuo. Acetone was added to the residue, and the precipitated crystals were collected by filtration. The crystals were recrystallized from ethanol-acetone, to give N-cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide dihydrobromide (0.46 g) as crystalline substances (yield based on N-cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide: 69.2%).

Provenance & Evidence