反应详情

N-Cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide (0.50 g, 1.02 mmol) prepared in the same manner as in Example 1 was dissolved in methanol (20 ml). A 47% hydrobromic acid solution (0.47 g, 2.75 mmol) was added thereto, and the solvent was then removed by evaporation in vacuo. Acetone was added to the residue, and the precipitated crystals were collected by filtration. The crystals were recrystallized from ethanol-acetone, to give N-cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide dihydrobromide (0.46 g) as crystalline substances (yield based on N-cyclopropyl-6-[4-[(3-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide: 69.2%).

1. customthe solvent was then removed by evaporation in vacuo
2. additionAcetone was added to the residue
3. filtrationthe precipitated crystals were collected by filtration
4. customThe crystals were recrystallized from ethanol-acetone