Methyl iodide → HCID 18472417, compound

HRID 565902Notes

Reaction equation

HRID 565902 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([C:17]3[CH2:18][C:19]4[C:24]([CH:25]=3)=[CH:23][C:22]([C:26]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=3)=[CH:21][CH:20]=4)=[O:16])=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:33][I:34]>CN(C=O)C>[I-:34].[CH3:32][C:29]1[CH:28]=[CH:27][C:26]([C:22]2[CH:23]=[C:24]3[C:19](=[CH:20][CH:21]=2)[CH2:18][C:17]([C:15]([NH:14][C:11]2[CH:12]=[CH:13][C:8]([CH2:7][N+:1]4([CH3:33])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[CH:9][CH:10]=2)=[O:16])=[CH:25]3)=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18472566HCID 18472566, compound

Product 1

HCID 18472417HCID 18472417, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In DMF (10ml) was dissolved N-[4-(piperidinomethyl)-phenyl]-5-(4-methylphenyl)indene-2-carboxamide (400mg), and to the mixture was added methyl iodide (177 μl). The mixture was stirred at room temperature for 86 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give 1-[4-[5-(4-methylphenyl)indene-2-carboxamido]-benzyl]-1-methyl-piperidinium iodide (Compound 61) (516mg) as pale yellow crystals.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-0f40d4ad8f29401e98e8b42ed98ebaef
Source dataset
uspto-grants-2001_01
Patent number
US06172061B2

Reaction notes

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