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HRID565924

反应详情

EQUATION

反应方程式

HRID 565924 的结构方程式

REACTANTS

反应物

2
结构：CI
HCID6328

Methyl iodide

CH3I

结构：COc1ccc(-c2cccc(C=CC(=O)Nc3ccc(CN4CCCCC4)cc3)c2)cc1
HCID54111866

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(-c2cccc(C=CC(=O)Nc3ccc(C[N+]4(C)CCCCC4)cc3)c2)cc1.[I-]
HCID86756161

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 1-(4-(3-(4-methoxyphenyl)cinnamoyl-amino)benzyl)piperidine (0.32g) and methyl iodide (0.2ml) in dimethylformamide (5ml) was stirred at room temperature over night. The solvent was evaporated, and to the residue was added ethyl acetate. Precipitated crude crystal was filtered, which were recrystallized from ethanol-hexane to give 1-methyl-1-(4-(3-(4-methoxyphenyl)cinnamoylamino)-benzyl)piperidinium iodide (Compound 88) (0.33g) as pale brown crystals.

WORKUP

后处理

  1. customThe solvent was evaporated
  2. additionto the residue was added ethyl acetate
  3. customPrecipitated crude crystal
  4. filtrationwas filtered
  5. customwhich were recrystallized from ethanol-hexane