Hydrochloric Acid → HCID 18472401, compound

HRID 566112Notes

Reaction equation

HRID 566112 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:16][CH2:15][CH2:14][C:13]([C:17]([O:19]CC)=[O:18])=[CH:12][C:11]=3[CH:22]=2)[CH2:3][CH2:2]1.[OH-].[Na+].Cl>CO>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:16][CH2:15][CH2:14][C:13]([C:17]([OH:19])=[O:18])=[CH:12][C:11]=3[CH:22]=2)[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18472369HCID 18472369, compound

Product 1

HCID 18472401HCID 18472401, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In methanol (8 ml) was dissolved ethyl 7-morpholino-2,3-dihydro-1-benzoxepine-4-carboxylate (800 mg, 2.64 mmol), and to the mixture was added 1N sodium hydroxide solution (8 ml). The mixture was stirred at room temperature for 12 hours, and to the mixture was added 1N hydrochloric acid (8 ml). The organic solvent was evaporated under reduced pressure, and the precipitated insoluble materials were filtered, which were washed with water and diisopropylether and dried under reduced pressure to give 7-morpholino-2,3-dihydro-1-benzoxepine-4-carboxylic acid (649 mg, 2.36 mmol, 89%).

Workup

  1. customThe organic solvent was evaporated under reduced pressure
  2. filtrationthe precipitated insoluble materials were filtered
  3. washwhich were washed with water and diisopropylether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-f0f5799ad80a4292a06358b31ec8514a
Source dataset
uspto-grants-2001_01
Patent number
US06172061B2

Reaction notes

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