反应详情

温度

110 °C

A mixture of 4-nitrobenzylamine (6.09 g, 40.0 mmol), 2-chloropyrimidine (4.82 g, 42.1 mmol), triethylamine (11.2 ml, 80.4 mmol) and ethanol (120 ml) was stirred at 110° C. for 24 hours, and the mixture was concentrated under reduced pressure. To the residue was added water, and the mixture was extracted with ethyl acetate-THF. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-ethanol to give N-(4-nitrobenzyl)-N-(2-pyrimidinyl)amine (0.99 g, 4.3 mmol, 11%).

1. concentrationthe mixture was concentrated under reduced pressure
2. additionTo the residue was added water
3. extractionthe mixture was extracted with ethyl acetate-THF
4. dry with materialThe organic layer was dried with anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue was recrystallized from ethyl acetate-ethanol