反应详情

2.8 ml (20.1 mmol, 2.5 eq.) of triethylamine were added to a solution of 2.3 g (8.0 mmol) of 3-[2-(4-nitrophenyl)-2-oxoethyl]-1,3-thiazolidine-2,4-dione in 80 ml of ethanol, and the mixture was stirred under reflux for 14 h. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in water/ethyl acetate. After phase separation, the organic phase was dried (sodium sulphate), filtered, concentrated under reduced pressure and dried. The residue was stirred in dichloromethane and the precipitate was filtered off and dried under reduced pressure. Yield: 1.1 g (67% of theory)

1. temperatureunder reflux for 14 h
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. dissolutionthe residue was dissolved in water/ethyl acetate
4. customAfter phase separation
5. dry with materialthe organic phase was dried (sodium sulphate)
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customdried
9. stirringThe residue was stirred in dichloromethane
10. filtrationthe precipitate was filtered off
11. customdried under reduced pressure