2-Amino-5-bromobenzenemethanol → 2-Amino-5-bromobenzaldehyde

HRID 566140Notes

Reaction equation

HRID 566140 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][OH:10]>[O-2].[O-2].[Mn+4].CC(C)=O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]=[O:10]

Participants

4

Reactant 1

HCID 110308742-Amino-5-bromobenzenemethanol

Product 1

HCID 235104752-Amino-5-bromobenzaldehydeYield 71.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

To acetone (300 ml) were added (2-amino-5-bromophenyl)methanol (23.32 g) and active manganese dioxide (58.5 g), and the mixture was stirred at room temperature for 17.5 hours and filtered. The solvent was evaporated under reduced pressure to give 2-amino-5-bromobenzaldehyde (16.41 g, 71%).

Workup

  1. filtrationfiltered
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-65c40bbacbb4473ebb9494df3de6cedb
Source dataset
uspto-grants-2001_01
Patent number
US06172061B2

Reaction notes

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