反应详情

5-Amino-2-bromo-4-fluorophenol (30.9 g), allyl bromide (21.8 g) and potassium carbonate (22.77 g) were suspended in acetonitrile (300 ml), and the mixture was stirred at room temperature for 12 hours. After the reaction, the precipitates were filtered, the solvent was distilled off, and this was extracted with ethyl acetate. After washing with water, it was dried over anhydrous magnesium sulfate. Then, ethyl acetate was distilled off and the resulting oily substance was purified by chromatography on silica gel (ethyl acetate:n-hexane=1:3) to obtain the objective 5-allyloxy-4-bromo-2-fluoroaniline (12.14 g).

1. customAfter the reaction
2. filtrationthe precipitates were filtered
3. distillationthe solvent was distilled off
4. extractionthis was extracted with ethyl acetate
5. washAfter washing with water, it
6. dry with materialwas dried over anhydrous magnesium sulfate
7. distillationThen, ethyl acetate was distilled off
8. customthe resulting oily substance was purified by chromatography on silica gel (ethyl acetate:n-hexane=1:3)