反应详情

6-(2-Acetylthioethyl)-2-pyridylamine (0.56 g) was dissolved in methanol (10 ml). To the solution was added, at 0° C., sodium methylate (a 4.9N methanol solution, 0.58 ml), and the mixture was stirred for 30 minutes. To the reaction mixture was added iN hydrochloric acid (2.85 ml), followed by concentration under reduced pressure. To the concentrate was added ethyl acetate (10 ml), which was subjected to extraction. The extract solution was dried over anhydrous magnesium sulfate, followed by concentration to leave the title compound as an oily product (0.43 g).

1. additionTo the solution was added, at 0° C.
2. concentrationfollowed by concentration under reduced pressure
3. additionTo the concentrate was added ethyl acetate (10 ml), which
4. extractionwas subjected to extraction
5. dry with materialThe extract solution was dried over anhydrous magnesium sulfate
6. concentrationfollowed by concentration