反应详情

3-[2-(4-Toluenesulfonyloxy)propyl]pyridazine (2.53 g) was dissolved in acetone (50 ml). To the solution was added potassium thioacetate (1.48 g), and the mixture was stirred for 4.5 hours under reflux. The reaction mixture was concentrated under reduced pressure. To the concentrate was added water (30 ml), which was subjected to extraction with ethyl acetate. The extract solution was dried over anhydrous magnesium sulfate, which was concentrated under reduced pressure. The concentrate was purified by a silica gel column chromatography (developing solvent: ethyl acetate-hexane 4:1→1:0) to afford the title compound (1.18 g).

1. temperatureunder reflux
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additionTo the concentrate was added water (30 ml), which
4. extractionwas subjected to extraction with ethyl acetate
5. dry with materialThe extract solution was dried over anhydrous magnesium sulfate, which
6. concentrationwas concentrated under reduced pressure
7. customThe concentrate was purified by a silica gel column chromatography (developing solvent: ethyl acetate-hexane 4:1→1:0)