3-[2-(4-Toluenesulfonyloxy)propyl]pyridazine → 3-(2-Acetylthiopropyl)pyridazine

Participants

Reaction Steps

3-[2-(4-Toluenesulfonyloxy)propyl]pyridazine (2.53 g) was dissolved in acetone (50 ml). To the solution was added potassium thioacetate (1.48 g), and the mixture was stirred for 4.5 hours under reflux. The reaction mixture was concentrated under reduced pressure. To the concentrate was added water (30 ml), which was subjected to extraction with ethyl acetate. The extract solution was dried over anhydrous magnesium sulfate, which was concentrated under reduced pressure. The concentrate was purified by a silica gel column chromatography (developing solvent: ethyl acetate-hexane 4:1→1:0) to afford the title compound (1.18 g).

Provenance & Evidence