反应详情

To a solution of 2-fluorophenylacetic acid (450 g, 3.0 mol) in CH2Cl2 (900 mL) is added SOCl2 (714 g, 6 mol) dropwise. After addition is complete, the reaction mixture is heated to reflux for 2 hours. Subsequently, the solvent is removed in vacuo after which vacuum distillation of the resulting oil provides 2-fluorobenzeneacetyl chloride.

1. additionAfter addition
2. temperaturethe reaction mixture is heated
3. temperatureto reflux for 2 hours
4. customSubsequently, the solvent is removed in vacuo
5. distillationafter which vacuum distillation of the resulting oil