HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(2-Fluorophenyl)acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Benzeneacetic acid, 2-fluoro- | HCID 67979 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(2-Fluorophenyl)acetyl chloride | HCID 14004011 | — |
Reaction Steps
To a solution of 2-fluorophenylacetic acid (450 g, 3.0 mol) in CH2Cl2 (900 mL) is added SOCl2 (714 g, 6 mol) dropwise. After addition is complete, the reaction mixture is heated to reflux for 2 hours. Subsequently, the solvent is removed in vacuo after which vacuum distillation of the resulting oil provides 2-fluorobenzeneacetyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06174888B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-0085fa34a5ab406aba87447bb04026e8 |
| Source note | uspto-grants-2001_01 |